{"id":5924,"date":"2017-01-30T11:44:22","date_gmt":"2017-01-30T09:44:22","guid":{"rendered":"https:\/\/www.famelab.gr\/?p=5924"},"modified":"2025-10-30T08:22:22","modified_gmt":"2025-10-30T08:22:22","slug":"role-of-ucp1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases","status":"publish","type":"post","link":"https:\/\/famelab.gr\/el\/role-of-ucp1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases\/","title":{"rendered":"Role of UCP1 gene variants in interethnic differences in the development of cardio-metabolic diseases"},"content":{"rendered":"<p><span style=\"color: #000000;\"> <a href=\"https:\/\/famelab.gr\/el\/role-of-ucp1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases\/\"><img decoding=\"async\" class=\"alignright wp-image-4122\" title=\"FAME Lab - Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/07\/45-1.jpg\" alt=\"FAME Lab - Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases\" width=\"300\" height=\"137\" \/><\/a><a href=\"https:\/\/famelab.gr\/el\/people\/\" target=\"_blank\" rel=\"noopener noreferrer\">Flouris AD<\/a>, Shidlovskii YV, Shaposhnikov AV, Yepiskoposyan L, Nadolnik L, Karabon L, Kowalska A, <a href=\"https:\/\/famelab.gr\/el\/people\/\" target=\"_blank\" rel=\"noopener noreferrer\">Carrillo AE<\/a>, Metsios GS and Sakellariou P (2017) Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases. Front. Genet. 8:7. doi: 10.3389\/fgene.2017.00007.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Abstract:<\/strong><\/span><\/p>\n<p>Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic pathological conditions with adverse consequences for cardiovascular function and metabolic processes. A wide range of CMD prevalence rates among different ethnic groups has been documented. In view of accumulated evidence, there is a trend toward increasing CMD prevalence rates in Eastern Europe and Western Asia. Numerous studies have revealed an association between uncoupling protein 1 (<i>UCP1<\/i>) gene variants and CMDs. UCP1 activity is essential for brown adipose tissue (BAT)-mediated thermogenesis.<\/p>\n<p>Experimental animal studies and epidemiological studies in humans highlight the significance of BAT-mediated thermogenesis in protecting against obesity and maintaining a lean phenotype. We hypothesize that the genetic variation in\u00a0<i>UCP1<\/i>\u00a0gene expression observed among different ethnic groups could contribute to the ethnic-specific predisposition to CMD development. Constructing such prevalence maps of\u00a0<i>UCP1<\/i>\u00a0gene variants could contribute significantly into identifying high-risk ethnic groups predisposed to the development of CMDs, and further shaping public health policies by the improvement of existing preventive and management strategies.<\/p>\n<p><span style=\"color: #000000;\"><strong>Full Text Link: <\/strong><\/span><\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2017.00007\/full\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2017.00007\/full<\/a><\/p>\n<p><span style=\"color: #000000;\"><strong>Download PDF:<\/strong><\/span><\/p>\n<p><a href=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2022\/04\/Role-of-UCP1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases_2017.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.famelab.gr\/wp-content\/uploads\/2022\/04\/Role-of-UCP1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases_2017.pdf<\/a><\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-8302 size-full\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/11\/Line.png\" alt=\"\" width=\"1316\" height=\"1\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Flouris AD, Shidlovskii YV, Shaposhnikov AV, Yepiskoposyan L, Nadolnik L, Karabon L, Kowalska A, Carrillo AE, Metsios GS and Sakellariou P (2017) Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases. Front. Genet. 8:7. doi: 10.3389\/fgene.2017.00007. Abstract: Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-5924","post","type-post","status-publish","format-standard","hentry","category-fame-lab-publications-2017"],"_links":{"self":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/5924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/comments?post=5924"}],"version-history":[{"count":1,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/5924\/revisions"}],"predecessor-version":[{"id":16606,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/5924\/revisions\/16606"}],"wp:attachment":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/media?parent=5924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/categories?post=5924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/tags?post=5924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}