{"id":6154,"date":"2016-01-19T08:30:42","date_gmt":"2016-01-19T06:30:42","guid":{"rendered":"https:\/\/www.famelab.gr\/?p=6154"},"modified":"2025-10-30T08:27:03","modified_gmt":"2025-10-30T08:27:03","slug":"a-low-protein-high-carbohydrate-diet-stimulates-thermogenesis-in-the-brown-adipose-tissue-of-rats-via-atf-2","status":"publish","type":"post","link":"https:\/\/famelab.gr\/el\/a-low-protein-high-carbohydrate-diet-stimulates-thermogenesis-in-the-brown-adipose-tissue-of-rats-via-atf-2\/","title":{"rendered":"A low-protein, high-carbohydrate diet stimulates thermogenesis in the brown adipose tissue of rats via ATF-2"},"content":{"rendered":"<p><span style=\"color: #000000;\"> <a href=\"https:\/\/famelab.gr\/el\/a-low-protein-high-carbohydrate-diet-stimulates-thermogenesis-in-the-brown-adipose-tissue-of-rats-via-atf-2\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignright wp-image-4157 size-medium\" title=\"FAME Lab - A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/07\/60-300x178.png\" alt=\"FAME Lab - A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2\" width=\"300\" height=\"178\" \/><\/a>de Fran\u00e7a SA, dos Santos MP, Przygodda F, Gar\u00f3falo MA, Kettelhut IC, Magalh\u00e3es DA, Bezerra KS, Colodel EM, <a href=\"https:\/\/famelab.gr\/el\/people\/\" target=\"_blank\" rel=\"noopener noreferrer\">Flouris AD<\/a>, Andrade CM, Kawashita NH. A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2. Lipids. 2016 Mar;51(3):303-10. doi: 10.1007\/s11745-016-4119-z. Epub 2016 Jan 19. PMID: 26781764.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Abstract:<\/strong><\/span><\/p>\n<p>The aim of this study was to evaluate thermogenesis in the interscapular brown adipose tissue (IBAT) of rats submitted to low-protein, high-carbohydrate (LPHC) diet and the involvement of adrenergic stimulation in this process.<\/p>\n<p>Male rats (~100 g) were submitted to LPHC (6%-protein; 74%-carbohydrate) or control (C; 17%-protein; 63%-carbohydrate) isocaloric diets for 15 days. The IBAT temperature was evaluated in the rats before and after the administration of noradrenaline (NA) (20 \u00b5g 100 g b w(-1) min(-1)). The expression levels of uncoupling protein 1 (UCP1) and other proteins involved in the regulation of UCP1 expression were determined by Western blot (Student&#8217;s t test, P \u2264 0.05). The LPHC diet promoted a 1.1 \u00b0C increase in the basal temperature of IBAT when compared with the basal temperature in the IBAT of the C group. NA administration promoted a 0.3 \u00b0C increase in basal temperature in the IBAT of the C rats and a 0.5 \u00b0C increase in the IBAT of the LPHC group.<\/p>\n<p>The level of UCP1 increased 60% in the IBAT of LPHC-fed rats, and among the proteins involved in its expression, such as \u03b23-AR and \u03b11-AR, there was a 40% increase in the levels of p38-MAPK and a 30% decrease in CREB when compared to the C rats. The higher sympathetic flux to IBAT, which is a consequence of the administration of the LPHC diet to rats, activates thermogenesis and increases the expression of UCP1 in the tissue. Our results suggest that the increase in UCP1 content may occur via p38 MAPK and ATF2.<\/p>\n<p><span style=\"color: #000000;\"><strong>Full Text Link: <\/strong><\/span><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26781764\/\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26781764\/<\/a><\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-8302 size-full\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/11\/Line.png\" alt=\"\" width=\"1316\" height=\"1\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>de Fran\u00e7a SA, dos Santos MP, Przygodda F, Gar\u00f3falo MA, Kettelhut IC, Magalh\u00e3es DA, Bezerra KS, Colodel EM, Flouris AD, Andrade CM, Kawashita NH. A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2. Lipids. 2016 Mar;51(3):303-10. doi: 10.1007\/s11745-016-4119-z. Epub 2016 Jan 19. PMID: 26781764. Abstract: The aim of this [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[],"class_list":["post-6154","post","type-post","status-publish","format-standard","hentry","category-fame-lab-publications-2016"],"_links":{"self":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/comments?post=6154"}],"version-history":[{"count":1,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6154\/revisions"}],"predecessor-version":[{"id":16617,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6154\/revisions\/16617"}],"wp:attachment":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/media?parent=6154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/categories?post=6154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/tags?post=6154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}