{"id":6180,"date":"2015-12-01T10:52:45","date_gmt":"2015-12-01T08:52:45","guid":{"rendered":"https:\/\/www.famelab.gr\/?p=6180"},"modified":"2025-10-30T08:28:00","modified_gmt":"2025-10-30T08:28:00","slug":"the-absorption-and-metabolism-of-a-single-l-menthol-oral-versus-skin-administration-effects-on-thermogenesis-and-metabolic-rate","status":"publish","type":"post","link":"https:\/\/famelab.gr\/el\/the-absorption-and-metabolism-of-a-single-l-menthol-oral-versus-skin-administration-effects-on-thermogenesis-and-metabolic-rate\/","title":{"rendered":"The absorption and metabolism of a single l-menthol oral versus skin administration: effects on thermogenesis and metabolic rate"},"content":{"rendered":"<p><span style=\"color: #000000;\"> <a href=\"https:\/\/famelab.gr\/el\/the-absorption-and-metabolism-of-a-single-l-menthol-oral-versus-skin-administration-effects-on-thermogenesis-and-metabolic-rate\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignright wp-image-4163 size-medium\" title=\"FAME Lab - The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/07\/62-245x300.jpg\" alt=\"FAME Lab - The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate\" width=\"245\" height=\"300\" \/><\/a>Valente A, Carrillo AE, Tzatzarakis MN, Vakonaki E, Tsatsakis AM, Kenny GP, Koutedakis Y, Jamurtas AZ, <a href=\"https:\/\/famelab.gr\/el\/people\/\" target=\"_blank\" rel=\"noopener noreferrer\">Flouris AD<\/a>. The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate. Food Chem Toxicol. 2015 Dec;86:262-73. doi: 10.1016\/j.fct.2015.09.018. Epub 2015 Sep 30. PMID: 26429629.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Abstract:<\/strong><\/span><\/p>\n<p>We investigated the absorption and metabolism pharmacokinetics of a single L-menthol oral versus skin administration and the effects on human thermogenesis and metabolic rate.\u00a0Twenty healthy adults were randomly distributed into oral (capsule) and skin (gel) groups and treated with 10 mg kg(-1) L-menthol (ORALMENT; SKINMENT) or control (lactose capsule: ORALCON; water application: SKINCON) in a random order on two different days. Levels of serum L-menthol increased similarly in ORALMENT and SKINMENT (p &gt; 0.05).<\/p>\n<p>L-menthol glucuronidation was greater in ORALMENT than SKINMENT (p &lt; 0.05). Cutaneous vasoconstriction, rectal temperature and body heat storage showed greater increase following SKINMENT compared to ORALMENT and control conditions (p &lt; 0.05). Metabolic rate increased from baseline by 18% in SKINMENT and 10% in ORALMENT and respiratory exchange ratio decreased more in ORALMENT (5.4%) than SKINMENT (4.8%) compared to control conditions (p &lt; 0.05). Levels of plasma adiponectin and leptin as well as heart rate variability were similar to control following either treatment (p &gt; 0.05). Participants reported no cold, shivering, discomfort, stress or skin irritation. We conclude that a single L-menthol skin administration increased thermogenesis and metabolic rate in humans. These effects are minor following L-menthol oral administration probably due to faster glucuronidation and greater blood menthol glucuronide levels.<\/p>\n<p><span style=\"color: #000000;\"><strong>Full Text Link: <\/strong><\/span><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26429629\/\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26429629\/<\/a><\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-8302 size-full\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/11\/Line.png\" alt=\"\" width=\"1316\" height=\"1\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Valente A, Carrillo AE, Tzatzarakis MN, Vakonaki E, Tsatsakis AM, Kenny GP, Koutedakis Y, Jamurtas AZ, Flouris AD. The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate. Food Chem Toxicol. 2015 Dec;86:262-73. doi: 10.1016\/j.fct.2015.09.018. Epub 2015 Sep 30. PMID: 26429629. Abstract: We investigated the absorption and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[44],"tags":[],"class_list":["post-6180","post","type-post","status-publish","format-standard","hentry","category-fame-lab-publications-2015"],"_links":{"self":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/comments?post=6180"}],"version-history":[{"count":1,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6180\/revisions"}],"predecessor-version":[{"id":16620,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6180\/revisions\/16620"}],"wp:attachment":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/media?parent=6180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/categories?post=6180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/tags?post=6180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}