{"id":6263,"date":"2015-10-12T10:31:10","date_gmt":"2015-10-12T08:31:10","guid":{"rendered":"https:\/\/www.famelab.gr\/?p=6263"},"modified":"2025-10-30T08:28:44","modified_gmt":"2025-10-30T08:28:44","slug":"shaping-our-understanding-of-endothermic-thermoregulation","status":"publish","type":"post","link":"https:\/\/famelab.gr\/el\/shaping-our-understanding-of-endothermic-thermoregulation\/","title":{"rendered":"Shaping our understanding of endothermic thermoregulation"},"content":{"rendered":"<p><span style=\"color: #000000;\"> <a href=\"https:\/\/famelab.gr\/el\/shaping-our-understanding-of-endothermic-thermoregulation\/\"><img decoding=\"async\" class=\"alignright wp-image-6267 size-full\" title=\"Shaping our understanding of endothermic thermoregulation\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2022\/02\/retgdfxv-xc.png\" alt=\"Shaping our understanding of endothermic thermoregulation\" width=\"271\" height=\"94\" \/><\/a><a href=\"https:\/\/famelab.gr\/el\/people\/\" target=\"_blank\" rel=\"noopener noreferrer\">Flouris AD<\/a>. Shaping our understanding of endothermic thermoregulation. Temperature (Austin). 2015 Oct 12;2(3):328-9. doi: 10.1080\/23328940.2015.1058321. PMID: 27227039; PMCID: PMC4843907.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Abstract:<\/strong><\/span><\/p>\n<p>The paper by Kobayashi entitled \u201cTemperature receptors in cutaneous nerve endings are thermostat molecules that induce thermoregulatory behaviors against thermal load\u201d1 summarizes a series of elegant studies conducted by Kobayashi and colleagues during the past 30 years. These studies have challenged the \u201chypothalamic proportional control\u201d model which remains the most widely accepted approach for the functional architecture of endothermic thermoregulation over the past 50+ years.2 Kobayashi opposes the dogma that receptors are sensors, arguing instead that receptors are \u201ccomparators.\u201d<\/p>\n<p>He proposes that heat- and cold-sensitive neurons are comparators of temperature and evoke impulses when temperature surpasses a receptor activation threshold. In turn, these impulses are not a form of neural code (as assumed by the \u201chypothalamic proportional control\u201d model) but they are actually triggers to activate target effector neurons in the brain. For instance, when skin temperature is below its threshold value, peripheral cold-sensitive neurons evoke impulses to stimulate target neurons in the brain responsible for appropriate heat-seeking responses. Consequently, skin coolness \u201c\u2026only occurs in the sensation world in our mind.\u201d3 Ergo, the \u201ccomparator\u201d model suggests that effectors are triggered via sensory neurons directly, without the involvement\/presence of a separate decision-making network or temperature code computations.<\/p>\n<p><span style=\"color: #000000;\"><strong>Full Text Link: <\/strong><\/span><\/p>\n<p><a href=\"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23328940.2015.1058321?needAccess=true\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23328940.2015.1058321?needAccess=true<\/a><\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-8302 size-full\" src=\"https:\/\/www.famelab.gr\/wp-content\/uploads\/2021\/11\/Line.png\" alt=\"\" width=\"1316\" height=\"1\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Flouris AD. Shaping our understanding of endothermic thermoregulation. Temperature (Austin). 2015 Oct 12;2(3):328-9. doi: 10.1080\/23328940.2015.1058321. PMID: 27227039; PMCID: PMC4843907. Abstract: The paper by Kobayashi entitled \u201cTemperature receptors in cutaneous nerve endings are thermostat molecules that induce thermoregulatory behaviors against thermal load\u201d1 summarizes a series of elegant studies conducted by Kobayashi and colleagues during the past [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[44],"tags":[],"class_list":["post-6263","post","type-post","status-publish","format-standard","hentry","category-fame-lab-publications-2015"],"_links":{"self":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/comments?post=6263"}],"version-history":[{"count":1,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6263\/revisions"}],"predecessor-version":[{"id":16622,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6263\/revisions\/16622"}],"wp:attachment":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/media?parent=6263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/categories?post=6263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/tags?post=6263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}