{"id":6963,"date":"2009-03-05T13:07:15","date_gmt":"2009-03-05T11:07:15","guid":{"rendered":"https:\/\/www.famelab.gr\/?p=6963"},"modified":"2025-10-30T09:14:57","modified_gmt":"2025-10-30T09:14:57","slug":"acute-and-short-term-effects-of-secondhand-smoke-on-lung-function-and-cytokine-production","status":"publish","type":"post","link":"https:\/\/famelab.gr\/el\/acute-and-short-term-effects-of-secondhand-smoke-on-lung-function-and-cytokine-production\/","title":{"rendered":"Acute and short-term effects of secondhand smoke on lung function and cytokine production"},"content":{"rendered":"

\"FAME<\/a> Flouris AD<\/a>, Metsios GS, Carrillo AE<\/a>, Jamurtas AZ, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. Acute and short-term effects of secondhand smoke on lung function and cytokine production. Am J Respir Crit Care Med. 2009 Jun 1;179(11):1029-33. doi: 10.1164\/rccm.200812-1920OC. Epub 2009 Mar 5. PMID: 19264972.<\/span><\/p>\n

Abstract:<\/strong><\/span><\/p>\n

Rationale: The acute effect of secondhand smoke (SHS) on lung function and the duration of system disruption remain unknown.<\/p>\n

Objectives: To assess the SHS effects and their duration on lung function and inflammatory markers.<\/p>\n

Methods: In a randomized single-blind crossover experiment data were obtained from 16 (8 women) nonsmoking adults at baseline and at 0, 1, and 3 hours after a 1-hour SHS exposure set at bar\/restaurant SHS levels. Measurements and main results: Serum and urine cotinine, lung function, and cytokines IL-4, IL-5, IL-6, tumor necrosis factor (TNF)-alpha, and IFN-gamma. At 0 hours most lung function parameters were significantly reduced (indicative: FEV(1), 4.3 +\/- 0.4 vs. 3.8 +\/- 0.3 L; FEV(1)\/FVC, 0.9 +\/- 0.1 vs. 0.8 +\/- 0.1; P < 0.05) but at 3 hours they were at baseline levels. In contrast, cotinine (serum, 8.9 +\/- 3.2 vs. 35.5 +\/- 10.2 ng x ml(-1)), IL-4 (41.3 +\/- 5.8 vs. 44.2 +\/- 4.5 pg x ml(-1)), IL-5 (36.1 +\/- 3.2 vs. 60.1 +\/- 7.0 pg x ml(-1)), IL-6 (2.5 +\/- 0.3 vs. 7.6 +\/- 1.4 pg x ml(-1)) and IFN-gamma (0.3 +\/- 0.2 vs. 0.6 +\/- 0.2 IU x ml(-1)) at 3 hours were higher than at baseline (P < 0.05). IL-4 and TNF-alpha increased only in men, whereas IL-5, IL-6, and IFN-gamma were different between sexes after exposure (P < 0.05). Regression analyses revealed inverse associations of FEV(1) and FEV(1)\/FVC ratio with IL-5 (P < 0.05) in men and with IL-5 (P = 0.01), IL-6 (P < 0.001), IFN-gamma (P = 0.034) and serum cotinine (P < 0.001) in women.<\/p>\n

Conclusions: We conclude that 1 hour of SHS exposure at bar\/restaurant levels is accompanied by significant decrements on lung function and marked increases in inflammatory cytokines, particularly in men. More importantly, whereas most smoke-induced effects on lung function appear to recede within 60 minutes, inflammatory cytokines remain elevated for at least 3 hours after exposure to SHS.<\/p>\n

Full Text Link: <\/strong><\/span><\/p>\n

https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.200812-1920OC<\/a><\/p>\n

Download PDF:<\/strong><\/span><\/p>\n

https:\/\/www.famelab.gr\/wp-content\/uploads\/2022\/04\/Acute-and-Short-term-Effects-of-Secondhand-Smoke-on-Lung-Function-and-Cytokine-Production_2009.pdf<\/a><\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

Flouris AD, Metsios GS, Carrillo AE, Jamurtas AZ, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. Acute and short-term effects of secondhand smoke on lung function and cytokine production. Am J Respir Crit Care Med. 2009 Jun 1;179(11):1029-33. doi: 10.1164\/rccm.200812-1920OC. Epub 2009 Mar 5. PMID: 19264972. Abstract: Rationale: The acute effect of secondhand […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[],"class_list":["post-6963","post","type-post","status-publish","format-standard","hentry","category-fame-lab-publications-2009"],"_links":{"self":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/comments?post=6963"}],"version-history":[{"count":1,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6963\/revisions"}],"predecessor-version":[{"id":16687,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/posts\/6963\/revisions\/16687"}],"wp:attachment":[{"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/media?parent=6963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/categories?post=6963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/famelab.gr\/el\/wp-json\/wp\/v2\/tags?post=6963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}