The FUEGO project, funded by the 7th Framework Programme of the European Commission, aimed to increase knowledge on adipose tissue plasticity and human thermogenesis. Through these activities, the FUEGO project fostered a mutual understanding of the different disciplines, encouraging entrepreneurship and long-term interdisciplinary collaboration regarding adipose tissue plasticity and human thermogenesis. The contribution of FUEGO to the study of adipose tissue plasticity and human thermogenesis was significant, as it became the means through which research centres collaborated in order to produce high-quality research. Exploiting the participants’ complementary expertise and creating synergies amongst them by fusing their research interests and specialisations in order to develop diverse research approaches, inexorably led to breakthroughs in our understanding of the mechanisms of adipose tissue plasticity and human thermogenesis.